Non sedating antihistamine drug list

Other common adverse effects in first-generation H-antihistamines include dizziness, tinnitus, blurred vision, euphoria, uncoordination, anxiety, increased appetite leading to weight gain, insomnia, tremor, nausea and vomiting, constipation, diarrhea, dry mouth, and dry cough.

Infrequent adverse effects include urinary retention, palpitations, hypotension, headache, hallucination, and psychosis.-receptors and have a better tolerability profile compared to the first-generation agents.

These agents also commonly have action at α-adrenergic receptors and/or 5-HT receptors.

This lack of receptor selectivity is the basis of the poor tolerability profile of some of these agents, especially when compared with the second-generation HDiphenhydramine was the prototypical agent in this group.

Once released, the histamine can react with local or widespread tissues through histamine receptors.-antihistamines help against these effects, they work only if taken before contact with the allergen.

In severe allergies, such as anaphylaxis or angioedema, these effects may be of life-threatening severity.

The isomerism is a significant factor in the activity of the agents in this group.

There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.

Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions.

The most common adverse effects noted for second-generation agents include drowsiness, fatigue, headache, nausea and dry mouth.-antihistaminergic drugs and are relatively inexpensive and widely available.

They are effective in the relief of allergic symptoms, but are typically moderately to highly potent muscarinic acetylcholine receptor (anticholinergic) antagonists as well.

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